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Cellular VitalityThursday 01/31/2013
Dr. DanDr. Dan Kuehne / Customized Clinical Nutritionist

Cellular Vitality


The new term for these cellular enhancing approaches is cytoprotective.  We have now discovered that there are genes dedicated to our survival.  We can up-regulate these genes with herbs and nutrients from our plants.  These pathways become quite complicated; however understanding the basics can help us literally live longer and healthier.


Cellular Vitality

  • Promoting cellular functions is the most upstream intervention in health care
  • Cellular function predicts disease cascades and defines resilience


NrF2/ARE Influences:

Antioxidant Response Element (ARE) is switched on by Nrf2 pathway. Current research has identified several important involvements in how the NrF2 pathways influences health maintenance and disease prevention

  • Health aging and longevity
  • Preventing cancer buildup
  • Radiation protection
  • Reducing oxidative stress and inflammation
  • Potential benefit in diseases resulting from accumulated toxins


All tissues express NrF2, but it is higher in detoxifying organs like the liver and kidneys.  NrF2 activates more than 200 known genes, enhancing DNA repair, heme metabolism, toxin transport mechanisms and glutathione synthesis.  It activates detoxification, stabilizes proteins, strengthens cellular integrity and reduces inflammatory activity and overgrowth. 


Old Antioxidant theory

  • When we metabolize we create free radical called Reactive oxygen species ROS
  • Take antioxidants that will neutralize free radical
  • Holes started appearing in the theory
  • Antioxidants can become pro-oxidants…in wrong environment can accelerate damage. An Example:
  • Green tea is beneficial on its own
  • Green tea after acetaminophen made liver damage


A new perspective on Antioxidants with the Nrf2 pathway:

  • Nrf2 ARE (antioxidant Response Element) pathway are better in long lived animals
  • Nrf2 activates more than 200 genes
  • Key phase II enzymes are also induced
  • Priming the pathway of Nrf2 creates up-regulation of cellular glutathione (a key antioxidant)
  • Key antioxidant enzymes are induced
  • NRf2 pathway switches on super oxide dismutase (SOD) inside the cells
  • SOD will quench 2 billion free radicals per second vs. antioxidant 1 per 1 free radical in old theory
  • Switching on this pathway has profound implications
  • Will help pull toxins and heavy metals



About Our Show Advisor: Dr. Dan Kuehne has a Bachelor of Science in Finance from Rutgers Business School and a Doctorate of Chiropractic from Life University.  He also has earned the distinction of Applied Clinical Nutritionist, after hundreds of hours of postgraduate education. Dr. Dan achieves remarkable results with his patients because of his dedication to serve his patients.  Dr. Dan learned early on the importance of customizing the care for each patient.  Dr. Dan uses the 7 Pillars of Health and the biofeedback system called, System Strength Analysis to achieve results with his Customized Clinical Nutrition program.  Using whole food supplements, herbs and empowerment education, Dr. Dan facilitates you reaching your health goals, naturally.  Dr. Dan Kuehne also is a gentle and specific chiropractor.  He uses instrument adjusting, and light force chiropractic techniques to restore the body’s vital life force from your brain to your body (every cell, tissue, muscle and organ) without any cracks, twists, or pops.  Dr. Dan motto is “Empowering People to Reach their God Given Potential.”  To learn more about Dr. Dan Kuehne and the techniques he uses visit his website at


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